Dr. Amy Winslow discovers a secret laboratory containing a sarcophagus, out of which springs a man who claims to be a real-life detective named Holmes, who, becoming uninspired by 1890s crime, devised this method to hibernate for a century to investigate future mysteries. Amy assumes he's a lunatic; it takes her a while to realize his amazing story is true. Holmes and Amy work together to solve a string of murders being committed by an exquisitely fiendish descendant of Holmes' Victorian archenemy, Professor Moriarty.