Lindsay Boxer is an inspector on the San Francisco Homicide Squad. Her healthy, optimistic outlook is given a jolt when she is diagnosed with aplastic anemia. While dealing with her first treatments, she takes on a new case. Someone has killed a bride and groom during the first hours of their honeymoon. The killer strikes again in Napa Valley and a third time in Cleveland. Lindsay gathers her girlfriends, all of whom work in related areas of the justice system, to circumvent the bureaucracy of police business and solve the crimes.