Captain Jack Sparrow finds the winds of ill-fortune blowing even more strongly when deadly ghost pirates led by his old nemesis, the terrifying Captain Salazar, escape from the Devil's Triangle, determined to kill every pirate at sea. His only hope of survival lies in seeking out the legendary Trident of Poseidon, a powerful artifact that bestows upon its possessor total control over the seas.

CIA agents Oakes and Pope are trying to purchase a suitcase-sized nuclear bomb from a Russian black marketer. Just as the partners discover that another bidder exists, they are ambushed and Pope is killed trying to protect Oakes. Now Oakes needs to recruit Pope's long lost twin brother, Jake, so that the deal can commence in ten days time. Offered a sizable payday, Jake agrees to undergo the vigorous training to impersonate his brother and helps Oakes...