Garfield's owner, Jon, takes in sweet, but dimwitted pooch Odie, turning Garfield's perfect world upside-down. Now Garfield wants only one thing: Odie out of his home and his life! But when the hapless pup disappears and is kidnapped by a nasty dog trainer, Garfield, feeling responsible, tears himself away from the TV and springs into action.

Samantha just wants a normal school experience away from her parents. The problem is her dad is the President of the United States! She heads off to college with Secret Service in tow and falls for a boy with secrets of his own.