Colonel Samantha Carter takes charge as the city's new leader, facing new and daunting challenges, including joining forces with the dangerous Wraith in order to fight a common enemy-- the seemingly unstoppable Replicators.

A group of soldiers, scientists and civilians, fleeing an attack, is stranded billions of miles from Earth on an Ancient ship known as the Destiny. Locked on an unknown course, they must fight to survive and find a way home. The danger, adventure and hope they find on board the Destiny will reveal the heroes and villains among them.

SG-1 searches for an ancient weapon which could help them defeat the Ori, and discover it may be in the Ori's own home galaxy. As the Ori prepare to send ships through to the Milky Way to attack Earth, on board the Odyssey, SG-1 travels to the Ori galaxy. The International Oversight Committee has their own plans and SG-1 finds themselves in a distant galaxy fighting two powerful enemies.